|[May 27, 2014]
New Research at CLEO: 2014 Could Lead to Precision-Guided Epidurals and Better Blood Monitors
WASHINGTON --(Business Wire)--
The march of modern medicine is often driven by revolutions in medical
imaging. When technology advances, doctors are better able to peer
deeply into human tissues, and thus able to detect, diagnose and treat
human diseases more effectively.
Now, researchers have taken an established imaging technology called
"optical coherence tomography," or OCT, and integrated it with other
instruments to bring about the next revolution in imaging by helping
doctors provide safer, less painful and more effective care for women in
labor and people with diabetic retinopathy and glaucoma. Their research
will be presented at CLEO:
2014 being held June 8-13 in San Jose, California, USA.
OCT uses scattered "echoes" or reflections of light waves to produce
high-resolution images of biological tissues, similar to ultrasound
imaging but with one order of magnitude improvement in the resolution.
Ophthalmologists have been using OCT to examine the retina for years.
More recently, OCT has been applied to a number of other clinical
specialties, including oncology for early cancer detection and staging
in the gastrointestinal and urogenital tract as well as in cardiology,
where it is used to study the formation of plaques in coronary arteries
Bioengineer Yu Chen of the University of Maryland and his colleagues
have developed a way to integrate an OCT device with an 18-gauge
epidural needle. Epidural administration, Chen notes, is traditionally
done blindly, using anatomical landmarks. But the team's newly
miniaturized handheld device lets anesthesiologists see tissue from the
perspective of the tip of the epidural needle, which could help doctors
to deliver spinal anesthetic to patients with less pain and fewer
"Due to lack of visual feedback, failure rates are often high, leading
to multiple needle insertions," he says. Side effects of these failures
can include trauma to blood vessels and punctures in the dura, the
outermost membrane surrounding the brain and spinal cord.
"An OCT forward-imagig probe can provide anesthesiologists with
real-time visualization of the microarchitecture of tissues and
important landmarks, and thus could significantly improve the accuracy
and the safety of the needle-based procedure," Chen says.
The researchers have been successful in testing needle-guidance
experiments on pig swine samples and hope to conduct a pre-clinical
study of the device within the next year.
Presentation AM2O.3, titled "Real-time Epidural Anesthesia Guidance
Using Optical Coherence Tomography Needle Probe will take place Monday,
June 9, at 11:15 a.m. in Salon V & VI of the San Jose Convention
Better blood monitors
A team at the University of California, Davis, led by Biomedical
Engineer Vivek Srinivasan has shown how OCT can simultaneously measure
blood flow and blood oxygenation in vessels, without the need for
Like ultrasound, OCT can provide structural information, but it can also
be used to determine flow rates and for angiography, visualizing the
interior of blood vessels, says Shau Poh Chong, a postdoctoral
researcher in the Srinivasan lab.
"Conventional pulse oximetry measures oxygen saturation using
transmitted light," Chong says. "Performing these measurements
quantitatively with reflected light has traditionally been difficult due
to the unknown distance traveled by the light through scattering tissue."
OCT directly determines the distance that light travels. Until now,
however, it was difficult to use OCT to measure oxygen saturation in
blood, due to additional modeling errors introduced by light scattering.
At visible wavelengths, scattering is much lower relative to blood
absorption than at infrared wavelengths, where OCT is typically
performed. The OCT system developed in the Srinivasan lab uses broadband
visible light to measure the amounts of both oxygenated and deoxygenated
hemoglobin, the oxygen-carrying protein of blood, thus revealing oxygen
saturation levels. In addition, the team developed new methods to
further reduce modeling errors caused by light scattering.
"The broad set of measurements provided by the system, including
angiography, oximetry and red blood cell flow rates enables the direct
assessment of tissue oxygen metabolism, which is essential for
understanding the evolution of oxygen supply and demand in numerous
disease models," Chong says. "In the future, these techniques could be
applied to study metabolic changes in diseases that affect the human
retina, such as diabetic retinopathy and glaucoma."
Presentation ATh1O.2, titled "Optical Coherence Imaging of Microvascular
Oxygenation and Hemodynamics will take place Thursday, June 12, at 8:30
a.m. in Willow Glen I - III of the San Jose Convention Marriott.
PRESS REGISTRATION: A press room for credentialed press and analysts
will be located in the San Jose Convention Center, Sunday through
Thursday, June 8-12. Those interested in obtaining a press badge for
CLEO: 2014 should contact Lyndsay Meyer at 202.416.1435 or firstname.lastname@example.org.
With a distinguished history as the industry's leading event on laser
science, the Conference on Lasers and Electro-Optics (CLEO) is the
premier international forum for scientific and technical optics, uniting
the fields of lasers and opto-electronics by bringing together all
aspects of laser technology, from basic research to industry
applications. CLEO: Expo showcases the latest products and applications
from more than 300 participating companies from around the world,
providing hands-on demonstrations of the latest market innovations and
applications. The Expo also offers valuable on-floor programming,
including Market Focus and the Technology Transfer program.
Sponsored by the American Physical Society's (APS) Laser Science
Division, IEEE (News - Alert) Photonics Society and The Optical Society (OSA), CLEO
provides the full range of critical developments in the field,
showcasing the most significant milestones from laboratory to
marketplace. With an unparalleled breadth and depth of coverage, CLEO
connects all of the critical vertical markets in lasers and
electro-optics. For more information, visit�www.cleoconference.org.
CLEO: 2014 takes place June 8 - 13 at the San Jose Convention Center.
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